The marathon will begin at Nyayo National Stadium and follow a route through some of Nairobi's busiest streets.
The BRT Line 5 will run along Outer Ring Road, from Taj Mall to Allsops, connecting with Thika Road.
Kenya Urban Roads Authority (KURA) urges motorists from the Prestige Plaza direction and the Daystar roundabout to seek alternative routes.
The CS noted that the vast regions need affirmative action, which are policies and practices aimed at benefiting marginalised parts of the country.
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